Research Impact: Skeletal muscle represents the largest organ in the body and has recently been recognised as having an endocrine function, whereby, proteins are synthesised in the muscle and released to have an effect on the function of muscle (autocrine), adjacent (paracrine) or distant (endocrine) tissues. These proteins are termed myokines. The primary stimulus for releasing myokines is muscle contraction during physical activity and exercise. Several hundred novel myokines have recently been identified, this paper outlines those which have a known function for regulating both fat and glucose metabolism. This paper also describes the type, duration and intensity of exercise which can maximise their release and harness their potential to impact Type 2 Diabetes.
Carson, B.P., 2017. The potential role of contraction-induced myokines in the regulation of metabolic function for the prevention and treatment of T2D. Frontiers in Endocrinology, 8, p.97. https://doi.org/10.3389/fendo.2017.00097