Research Impact: Benefits of exercise in multiple sclerosis (MS) are well-established, but clarity on safety is a hurdle in exercise prescription. Here we provide the protocol for a systematic review and meta-analysis that will synthesize relative risks of relapse, adverse events, and serious adverse events, as well as retention, adherence, and compliance from randomized controlled trials of exercise among people with MS, and identify sources of variability in outcomes. Random-effects meta-analysis will estimate mean population relative risk for outcomes. Participant characteristics, features of the exercise stimulus, and comparison condition, will be examined as potential moderators with random-effects meta-regression.
Learmonth YC, Pilutti LA, Herring MP, Motl RW, Chan B, Metse AP. (2021). Safety of exercise training in multiple sclerosis: A protocol for an updated systematic review and meta-analysis. Systematic Reviews, 10:208. (IF: 2.522; C=; Q2 Medicine, General & Internal; R=72/169) https://link.springer.com/article/10.1186/s13643-021-01751-0