Research Impact: Dietary calcium can affect bone health and fracture risk. The diurnal rhythm of bone remodeling suggests supplementing calcium in the late evening may be most effective. We wished to investigate if daily, bed-time ingestion of a calcium fortified, milk derived protein supplement could improve bone health more than a carbohydrate control in post-menopausal osteopaenic women. In a randomised, controlled trial we assessed changes to serum bone turnover markers and site specific bone mineral density over 24-weeks. We report statistically significant reductions in bone resorption markers (CTX) relative to the control, but no changes observed in bone formation markers (P1NP) or bone mineral density. We conclude that this study demonstrates the potential benefit of late-evening ingestion of a calcium-fortified, milk-based protein supplement on blood markers of bone remodelling but no resultant treatment effect on site-specific bone mineral density in osteopaenic, postmenopausal women.
Norton, C.; Hettiarachchi, M.; Cooke, R.; Kozior, M.; Kontro, H.; Daniel, R.; Jakeman, P. Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia. Nutrients 2022, 14, 3486. https://doi.org/10.3390/nu14173486